Mallick’s screen debut was in Haranath Chakraborty’s Nater Guru opposite Jeet. Nater Guru was a successful film at the box office. The film, released in 2003, marked Mallick’s entry into Tollywood. Nater Guru, which has Jeet in the male lead, sees Mallick playing the role of a 23-year-old girl called Monica. Since the release of Nater Guru the pair has worked together often, appearing in seven films.
In 2004, she starred in Devipaksha, Shudhu Tumi, Badshah and Bandhan. While the first two performed poorly at the box office, Badshah and Bandhan were more successful, with the latter going on to become a major money-earner.
In 2005, Mallick appeared in Shubha Drishti, Manik, Juddha and Chorey Chorey Mastuto Bhai. She also appeared in Juddha opposite actors Mithun Chakrabortyand Debasree Roy. The film recorded an initial collection of Rs. 1.2 crore in its first week. In 2006, she took on a more serious role in MLA Phatakeshto in which she played a reporter. She also starred in the Bengali remake of Love Story, the 2008 film Love.