A Sainik School alumnus, Indrajith got his degree in Computer Science from Rajas Engineering College near Nagercoil. He joined Nexage as a software professional before going into acting, where he first appeared in a television film called Annie. On December 13, 2002, he married actress Poornima Mohan. They have two daughters named Praarthana and Nakshatra.
His first cinematic role was in Ooomappenninu Uriyadappayyan, directed by Vinayan. He was noted for his villain role in the blockbuster Meesha Madhavan, directed by Lal Jose. He recently debuted in Tamil.
He acted alongside Mohanlal in Anwar Rasheed’s Chotta Mumbai and Shaji Kailas’s Baba Kalyani. His performance as the villain in Baba Kalyani was acclaimed by critics. His performances in Baba Kalyani, Ranjith’s Mizhi Randilum and Lal Jose’s Classmates were appreciated by critics and audiences alike. He also acted in Lal Jose’s superhit Arabikatha and Santhosh Sivan’s Before the Rains. He paired with his brother Prithviraj Sukumaran in several films, including the 2006 blockbuster Classmates. His movie Chekavar was a box-office blockbuster due to its Heavy Metal songs that were composed by composer Rahulraj.
His debut Hindi film, The Waiting Room, directed by Maneej Premnath, was released in January 2010.