Khan started his career as a film producer and director making his directorial debut with the 1997 action thriller Auzaar which starred his brother Salman and Sanjay Kapoor. He then directed both of his brothers Salman and Arbaaz in the hit film Pyaar Kiya To Darna Kya (1998) and the less successful Hello Brother (1999) under his earlier banner G.S. Entertainment.
In 2002, he wrote, produced, directed and made his acting debut in Maine Dil Tujhko Diya which performed poorly at the box office. He then appeared in a few more films, none of which sold well. He had his first hit with the film
Khan has also produced live stage shows in India and all over the world featuring various Indian film stars. His company also produced music videos and even made a foray into television with ‘Chehre Pe Chehra’ which was directed by Rishi Vohra.
He wrote the story, produced and acted in the multi-starrer Fight Club – Members Only which did not do well at the box office. His only 2007 release as an actor was the multi-starrer Salaam-e-Ishq: A Tribute To Love. He then produced Partner which starred his brother Salman and Govinda in the lead roles and was a box office success. In 2008, he has appeared in Hello and Heroes.
In 2010, he featured in Veer with brother Salman, released on 22 January 2010.